Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis
Identifieur interne : 000565 ( Main/Exploration ); précédent : 000564; suivant : 000566Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis
Auteurs : Konstantinos H. Katsanos [Grèce] ; Evangelos Briasoulis [Grèce] ; Pericles Tsekeris [Grèce] ; Anna Batistatou [Grèce] ; Maria Bai [Grèce] ; Christos Tolis [Grèce] ; Antonio Capizzello [Grèce] ; Ioannis Panelos [Grèce] ; Vasileios Karavasilis [Grèce] ; Dimitrios Christodoulou [Grèce] ; Epameinondas V. Tsianos [Grèce]Source :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2010.
Abstract
This study aimed to investigate the efficacy of prophylactic amifostine in reducing the risk of severe radiation colitis in cancer patients receiving radical radiotherapy to the pelvis.
Patients with pelvic tumours referred for radical radiotherapy who consented participation in this trial, were randomly assigned to receive daily amifostine (A) (subcutaneously, 500 mg flat dose) before radiotherapy or radiotherapy alone (R). Sigmoidoscopy and blinded biopsies were scheduled to conduct prior to initiation and following completion of radiotherapy and again 6 to 9 months later. Radiation colitis was assessed by clinical, endoscopic and histolopathological criteria.
A total 44 patients were enrolled in this trial, the majority with rectal (20 patients) and cervical cancer (12 patients) and were assigned 23 in R arm and 21 in the A arm. In total 119 sigmoidoscopies were performed and 18 patients (18/44, 40.9%) were diagnosed with radiation colitis (15 grade 1 and 2, and 3 grade 3 and 4). Of them, 6 patients belonged to the A group (6/21, 28.6%) and 12 to the R group (12/23, 52.2%). Acute and grade IV radiation colitis was only developed in four patients (17.4%) in the R group. Amifostine side effects were mild. Amifostine treated patients were less likely to develop histologically detectable mucosal lesions, which indicate protection from acute mucosal injury.
Amifostine given subcutaneously can lower the risk of acute severe radiation colitis in patients who receive radical radiotherapy to pelvic tumors.
Url:
DOI: 10.1186/1756-9966-29-68
PubMed: 20537164
PubMed Central: 2903531
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000434
- to stream Pmc, to step Curation: 000433
- to stream Pmc, to step Checkpoint: 000304
- to stream Ncbi, to step Merge: 000133
- to stream Ncbi, to step Curation: 000133
- to stream Ncbi, to step Checkpoint: 000133
- to stream Main, to step Merge: 000568
- to stream Main, to step Curation: 000565
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis</title><author><name sortKey="Katsanos, Konstantinos H" sort="Katsanos, Konstantinos H" uniqKey="Katsanos K" first="Konstantinos H" last="Katsanos">Konstantinos H. Katsanos</name><affiliation wicri:level="1"><nlm:aff id="I1">1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Briasoulis, Evangelos" sort="Briasoulis, Evangelos" uniqKey="Briasoulis E" first="Evangelos" last="Briasoulis">Evangelos Briasoulis</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Tsekeris, Pericles" sort="Tsekeris, Pericles" uniqKey="Tsekeris P" first="Pericles" last="Tsekeris">Pericles Tsekeris</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Batistatou, Anna" sort="Batistatou, Anna" uniqKey="Batistatou A" first="Anna" last="Batistatou">Anna Batistatou</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Bai, Maria" sort="Bai, Maria" uniqKey="Bai M" first="Maria" last="Bai">Maria Bai</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Tolis, Christos" sort="Tolis, Christos" uniqKey="Tolis C" first="Christos" last="Tolis">Christos Tolis</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Capizzello, Antonio" sort="Capizzello, Antonio" uniqKey="Capizzello A" first="Antonio" last="Capizzello">Antonio Capizzello</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Panelos, Ioannis" sort="Panelos, Ioannis" uniqKey="Panelos I" first="Ioannis" last="Panelos">Ioannis Panelos</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Karavasilis, Vasileios" sort="Karavasilis, Vasileios" uniqKey="Karavasilis V" first="Vasileios" last="Karavasilis">Vasileios Karavasilis</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Christodoulou, Dimitrios" sort="Christodoulou, Dimitrios" uniqKey="Christodoulou D" first="Dimitrios" last="Christodoulou">Dimitrios Christodoulou</name><affiliation wicri:level="1"><nlm:aff id="I1">1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Tsianos, Epameinondas V" sort="Tsianos, Epameinondas V" uniqKey="Tsianos E" first="Epameinondas V" last="Tsianos">Epameinondas V. Tsianos</name><affiliation wicri:level="1"><nlm:aff id="I1">1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20537164</idno><idno type="pmc">2903531</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903531</idno><idno type="RBID">PMC:2903531</idno><idno type="doi">10.1186/1756-9966-29-68</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000434</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000434</idno><idno type="wicri:Area/Pmc/Curation">000433</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000433</idno><idno type="wicri:Area/Pmc/Checkpoint">000304</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000304</idno><idno type="wicri:Area/Ncbi/Merge">000133</idno><idno type="wicri:Area/Ncbi/Curation">000133</idno><idno type="wicri:Area/Ncbi/Checkpoint">000133</idno><idno type="wicri:doubleKey">0392-9078:2010:Katsanos K:randomized:phase:ii</idno><idno type="wicri:Area/Main/Merge">000568</idno><idno type="wicri:Area/Main/Curation">000565</idno><idno type="wicri:Area/Main/Exploration">000565</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis</title><author><name sortKey="Katsanos, Konstantinos H" sort="Katsanos, Konstantinos H" uniqKey="Katsanos K" first="Konstantinos H" last="Katsanos">Konstantinos H. Katsanos</name><affiliation wicri:level="1"><nlm:aff id="I1">1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Briasoulis, Evangelos" sort="Briasoulis, Evangelos" uniqKey="Briasoulis E" first="Evangelos" last="Briasoulis">Evangelos Briasoulis</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Tsekeris, Pericles" sort="Tsekeris, Pericles" uniqKey="Tsekeris P" first="Pericles" last="Tsekeris">Pericles Tsekeris</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Batistatou, Anna" sort="Batistatou, Anna" uniqKey="Batistatou A" first="Anna" last="Batistatou">Anna Batistatou</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Bai, Maria" sort="Bai, Maria" uniqKey="Bai M" first="Maria" last="Bai">Maria Bai</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Tolis, Christos" sort="Tolis, Christos" uniqKey="Tolis C" first="Christos" last="Tolis">Christos Tolis</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Capizzello, Antonio" sort="Capizzello, Antonio" uniqKey="Capizzello A" first="Antonio" last="Capizzello">Antonio Capizzello</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Radiotherapy Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Panelos, Ioannis" sort="Panelos, Ioannis" uniqKey="Panelos I" first="Ioannis" last="Panelos">Ioannis Panelos</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pathology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Karavasilis, Vasileios" sort="Karavasilis, Vasileios" uniqKey="Karavasilis V" first="Vasileios" last="Karavasilis">Vasileios Karavasilis</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of *Medical Oncology, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Christodoulou, Dimitrios" sort="Christodoulou, Dimitrios" uniqKey="Christodoulou D" first="Dimitrios" last="Christodoulou">Dimitrios Christodoulou</name><affiliation wicri:level="1"><nlm:aff id="I1">1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author><author><name sortKey="Tsianos, Epameinondas V" sort="Tsianos, Epameinondas V" uniqKey="Tsianos E" first="Epameinondas V" last="Tsianos">Epameinondas V. Tsianos</name><affiliation wicri:level="1"><nlm:aff id="I1">1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School of Ioannina, Leoforos Stavrou Niarxou, Ioannina, 451 10</wicri:regionArea><wicri:noRegion>451 10</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Experimental & Clinical Cancer Research : CR</title><idno type="ISSN">0392-9078</idno><idno type="eISSN">1756-9966</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>This study aimed to investigate the efficacy of prophylactic amifostine in reducing the risk of severe radiation colitis in cancer patients receiving radical radiotherapy to the pelvis.</p></sec><sec><title>Methods</title><p>Patients with pelvic tumours referred for radical radiotherapy who consented participation in this trial, were randomly assigned to receive daily amifostine (A) (subcutaneously, 500 mg flat dose) before radiotherapy or radiotherapy alone (R). Sigmoidoscopy and blinded biopsies were scheduled to conduct prior to initiation and following completion of radiotherapy and again 6 to 9 months later. Radiation colitis was assessed by clinical, endoscopic and histolopathological criteria.</p></sec><sec><title>Results</title><p>A total 44 patients were enrolled in this trial, the majority with rectal (20 patients) and cervical cancer (12 patients) and were assigned 23 in R arm and 21 in the A arm. In total 119 sigmoidoscopies were performed and 18 patients (18/44, 40.9%) were diagnosed with radiation colitis (15 grade 1 and 2, and 3 grade 3 and 4). Of them, 6 patients belonged to the A group (6/21, 28.6%) and 12 to the R group (12/23, 52.2%). Acute and grade IV radiation colitis was only developed in four patients (17.4%) in the R group. Amifostine side effects were mild. Amifostine treated patients were less likely to develop histologically detectable mucosal lesions, which indicate protection from acute mucosal injury.</p></sec><sec><title>Conclusions</title><p>Amifostine given subcutaneously can lower the risk of acute severe radiation colitis in patients who receive radical radiotherapy to pelvic tumors.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Andreyev, Hj" uniqKey="Andreyev H">HJ Andreyev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmermann, Fb" uniqKey="Zimmermann F">FB Zimmermann</name></author><author><name sortKey="Feldmann, Hj" uniqKey="Feldmann H">HJ Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schumacher, C" uniqKey="Schumacher C">C Schumacher</name></author><author><name sortKey="Paul, K" uniqKey="Paul K">K Paul</name></author><author><name sortKey="Robbe, Y" uniqKey="Robbe Y">Y Robbe</name></author><author><name sortKey="Sicart, Mt" uniqKey="Sicart M">MT Sicart</name></author><author><name sortKey="Chanal, Jl" uniqKey="Chanal J">JL Chanal</name></author><author><name sortKey="Delard, R" uniqKey="Delard R">R Delard</name></author><author><name sortKey="Dubois, Jb" uniqKey="Dubois J">JB Dubois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keshavarzian, A" uniqKey="Keshavarzian A">A Keshavarzian</name></author><author><name sortKey="Haydek, J" uniqKey="Haydek J">J Haydek</name></author><author><name sortKey="Zabihi, R" uniqKey="Zabihi R">R Zabihi</name></author><author><name sortKey="Doria, M" uniqKey="Doria M">M Doria</name></author><author><name sortKey="D Astice, M" uniqKey="D Astice M">M D'Astice</name></author><author><name sortKey="Sorenson, Jr" uniqKey="Sorenson J">JR Sorenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Athanassiou, H" uniqKey="Athanassiou H">H Athanassiou</name></author><author><name sortKey="Antonadou, D" uniqKey="Antonadou D">D Antonadou</name></author><author><name sortKey="Coliarakis, N" uniqKey="Coliarakis N">N Coliarakis</name></author><author><name sortKey="Kouveli, A" uniqKey="Kouveli A">A Kouveli</name></author><author><name sortKey="Synodinou, M" uniqKey="Synodinou M">M Synodinou</name></author><author><name sortKey="Paraskevaidis, M" uniqKey="Paraskevaidis M">M Paraskevaidis</name></author><author><name sortKey="Sarris, G" uniqKey="Sarris G">G Sarris</name></author><author><name sortKey="Georgakopoulos, Gr" uniqKey="Georgakopoulos G">GR Georgakopoulos</name></author><author><name sortKey="Panousaki, K" uniqKey="Panousaki K">K Panousaki</name></author><author><name sortKey="Karageorgis, P" uniqKey="Karageorgis P">P Karageorgis</name></author><author><name sortKey="Throuvalas, N" uniqKey="Throuvalas N">N Throuvalas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decosse, Jj" uniqKey="Decosse J">JJ DeCosse</name></author><author><name sortKey="Rhodes, Rs" uniqKey="Rhodes R">RS Rhodes</name></author><author><name sortKey="Wentz, Wb" uniqKey="Wentz W">WB Wentz</name></author><author><name sortKey="Reagan, Jw" uniqKey="Reagan J">JW Reagan</name></author><author><name sortKey="Dworken, Hj" uniqKey="Dworken H">HJ Dworken</name></author><author><name sortKey="Holden, Wd" uniqKey="Holden W">WD Holden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gelfand, Md" uniqKey="Gelfand M">MD Gelfand</name></author><author><name sortKey="Tepper, M" uniqKey="Tepper M">M Tepper</name></author><author><name sortKey="Katz, La" uniqKey="Katz L">LA Katz</name></author><author><name sortKey="Binder, Hj" uniqKey="Binder H">HJ Binder</name></author><author><name sortKey="Yesner, R" uniqKey="Yesner R">R Yesner</name></author><author><name sortKey="Floch, Mh" uniqKey="Floch M">MH Floch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berthrong, M" uniqKey="Berthrong M">M Berthrong</name></author><author><name sortKey="Fajardo, Lf" uniqKey="Fajardo L">LF Fajardo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haboubi, Ny" uniqKey="Haboubi N">NY Haboubi</name></author><author><name sortKey="Schofield, Pf" uniqKey="Schofield P">PF Schofield</name></author><author><name sortKey="Rowland, Pl" uniqKey="Rowland P">PL Rowland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roswit, B" uniqKey="Roswit B">B Roswit</name></author><author><name sortKey="Malsky, Sj" uniqKey="Malsky S">SJ Malsky</name></author><author><name sortKey="Reid, Cb" uniqKey="Reid C">CB Reid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baron, Jh" uniqKey="Baron J">JH Baron</name></author><author><name sortKey="Connel, Am" uniqKey="Connel A">AM Connel</name></author><author><name sortKey="Lennard Jones, Je" uniqKey="Lennard Jones J">JE Lennard-Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bai, M" uniqKey="Bai M">M Bai</name></author><author><name sortKey="Papoudou Bai, A" uniqKey="Papoudou Bai A">A Papoudou-Bai</name></author><author><name sortKey="Horianopoulos, N" uniqKey="Horianopoulos N">N Horianopoulos</name></author><author><name sortKey="Grepi, C" uniqKey="Grepi C">C Grepi</name></author><author><name sortKey="Agnantis, Nj" uniqKey="Agnantis N">NJ Agnantis</name></author><author><name sortKey="Kanavaros, P" uniqKey="Kanavaros P">P Kanavaros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fajardo, Lf" uniqKey="Fajardo L">LF Fajardo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fenoglio Preiser, Cm" uniqKey="Fenoglio Preiser C">CM Fenoglio-Preiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klingerman, Mm" uniqKey="Klingerman M">MM Klingerman</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Scheffler, B" uniqKey="Scheffler B">B Scheffler</name></author><author><name sortKey="He, S" uniqKey="He S">S He</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="He, S" uniqKey="He S">S He</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Kligerman, Mm" uniqKey="Kligerman M">MM Kligerman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanson, Wr" uniqKey="Hanson W">WR Hanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phan, Tp" uniqKey="Phan T">TP Phan</name></author><author><name sortKey="Crane, Ch" uniqKey="Crane C">CH Crane</name></author><author><name sortKey="Janjan, Na" uniqKey="Janjan N">NA Janjan</name></author><author><name sortKey="Vrdoljak, E" uniqKey="Vrdoljak E">E Vrdoljak</name></author><author><name sortKey="Milas, L" uniqKey="Milas L">L Milas</name></author><author><name sortKey="Mason, Ka" uniqKey="Mason K">KA Mason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Josef, E" uniqKey="Ben Josef E">E Ben-Josef</name></author><author><name sortKey="Mesina, J" uniqKey="Mesina J">J Mesina</name></author><author><name sortKey="Shaw, Lm" uniqKey="Shaw L">LM Shaw</name></author><author><name sortKey="Bonner, Hs" uniqKey="Bonner H">HS Bonner</name></author><author><name sortKey="Shamsa, F" uniqKey="Shamsa F">F Shamsa</name></author><author><name sortKey="Porter, At" uniqKey="Porter A">AT Porter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delaney, Jp" uniqKey="Delaney J">JP Delaney</name></author><author><name sortKey="Bonsack, Me" uniqKey="Bonsack M">ME Bonsack</name></author><author><name sortKey="Felemovicius, I" uniqKey="Felemovicius I">I Felemovicius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, H" uniqKey="Ito H">H Ito</name></author><author><name sortKey="Komaki, R" uniqKey="Komaki R">R Komaki</name></author><author><name sortKey="Milas, L" uniqKey="Milas L">L Milas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halberg, Fe" uniqKey="Halberg F">FE Halberg</name></author><author><name sortKey="Larue, Sm" uniqKey="Larue S">SM LaRue</name></author><author><name sortKey="Rayner, Aa" uniqKey="Rayner A">AA Rayner</name></author><author><name sortKey="Burnel, Wm" uniqKey="Burnel W">WM Burnel</name></author><author><name sortKey="Powers, Be" uniqKey="Powers B">BE Powers</name></author><author><name sortKey="Chan, As" uniqKey="Chan A">AS Chan</name></author><author><name sortKey="Schell, Mc" uniqKey="Schell M">MC Schell</name></author><author><name sortKey="Gillette, El" uniqKey="Gillette E">EL Gillette</name></author><author><name sortKey="Phillips, Tl" uniqKey="Phillips T">TL Phillips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="France, Hg" uniqKey="France H">HG France</name></author><author><name sortKey="Jirtle, Rl" uniqKey="Jirtle R">RL Jirtle</name></author><author><name sortKey="Mansbach, Cm" uniqKey="Mansbach C">CM Mansbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Travis, El" uniqKey="Travis E">EL Travis</name></author><author><name sortKey="Thames, Hd" uniqKey="Thames H">HD Thames</name></author><author><name sortKey="Tucker, Sl" uniqKey="Tucker S">SL Tucker</name></author><author><name sortKey="Watkins, Tl" uniqKey="Watkins T">TL Watkins</name></author><author><name sortKey="Kiss, I" uniqKey="Kiss I">I Kiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Laar, Ja" uniqKey="Van Laar J">JA van Laar</name></author><author><name sortKey="Van Der Wilt, Cl" uniqKey="Van Der Wilt C">CL van der Wilt</name></author><author><name sortKey="Treskes, M" uniqKey="Treskes M">M Treskes</name></author><author><name sortKey="Van Der Vijgh, Wj" uniqKey="Van Der Vijgh W">WJ van der Vijgh</name></author><author><name sortKey="Peters, Gj" uniqKey="Peters G">GJ Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Wilt, Cl" uniqKey="Van Der Wilt C">CL van der Wilt</name></author><author><name sortKey="Van Laar, Ja" uniqKey="Van Laar J">JA van Laar</name></author><author><name sortKey="Gyergyay, F" uniqKey="Gyergyay F">F Gyergyay</name></author><author><name sortKey="Smid, K" uniqKey="Smid K">K Smid</name></author><author><name sortKey="Peters, Gj" uniqKey="Peters G">GJ Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bedwell, J" uniqKey="Bedwell J">J Bedwell</name></author><author><name sortKey="Chatlani, Pt" uniqKey="Chatlani P">PT Chatlani</name></author><author><name sortKey="Macrobert, Aj" uniqKey="Macrobert A">AJ MacRobert</name></author><author><name sortKey="Roberts, Je" uniqKey="Roberts J">JE Roberts</name></author><author><name sortKey="Barr, H" uniqKey="Barr H">H Barr</name></author><author><name sortKey="Dillon, J" uniqKey="Dillon J">J Dillon</name></author><author><name sortKey="Bown, Sg" uniqKey="Bown S">SG Bown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montana, Gs" uniqKey="Montana G">GS Montana</name></author><author><name sortKey="Anscher, Ms" uniqKey="Anscher M">MS Anscher</name></author><author><name sortKey="Mansbach, Cm" uniqKey="Mansbach C">CM Mansbach</name></author><author><name sortKey="Delannes, M" uniqKey="Delannes M">M Delannes</name></author><author><name sortKey="Carke Pearson, D" uniqKey="Carke Pearson D">D Carke-Pearson</name></author><author><name sortKey="Gaydica, Ef" uniqKey="Gaydica E">EF Gaydica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vorgias, G" uniqKey="Vorgias G">G Vorgias</name></author><author><name sortKey="Profitis, E" uniqKey="Profitis E">E Profitis</name></author><author><name sortKey="Sarris, G" uniqKey="Sarris G">G Sarris</name></author><author><name sortKey="Strigou, S" uniqKey="Strigou S">S Strigou</name></author><author><name sortKey="Kosmas, C" uniqKey="Kosmas C">C Kosmas</name></author><author><name sortKey="Katsoulis, M" uniqKey="Katsoulis M">M Katsoulis</name></author><author><name sortKey="Karamoussa, E" uniqKey="Karamoussa E">E Karamoussa</name></author><author><name sortKey="Kalinoglou, N" uniqKey="Kalinoglou N">N Kalinoglou</name></author><author><name sortKey="Koliarakis, N" uniqKey="Koliarakis N">N Koliarakis</name></author><author><name sortKey="Dertimas, B" uniqKey="Dertimas B">B Dertimas</name></author><author><name sortKey="Bafaloukos, D" uniqKey="Bafaloukos D">D Bafaloukos</name></author><author><name sortKey="Akrivos, T" uniqKey="Akrivos T">T Akrivos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicolatou Galitis, O" uniqKey="Nicolatou Galitis O">O Nicolatou-Galitis</name></author><author><name sortKey="Sotiropoulou Lontou, A" uniqKey="Sotiropoulou Lontou A">A Sotiropoulou-Lontou</name></author><author><name sortKey="Velegraki, A" uniqKey="Velegraki A">A Velegraki</name></author><author><name sortKey="Pissakas, G" uniqKey="Pissakas G">G Pissakas</name></author><author><name sortKey="Kolitsi, G" uniqKey="Kolitsi G">G Kolitsi</name></author><author><name sortKey="Kyprianou, K" uniqKey="Kyprianou K">K Kyprianou</name></author><author><name sortKey="Kouloulias, V" uniqKey="Kouloulias V">V Kouloulias</name></author><author><name sortKey="Papanikolaou, I" uniqKey="Papanikolaou I">I Papanikolaou</name></author><author><name sortKey="Yiotakis, I" uniqKey="Yiotakis I">I Yiotakis</name></author><author><name sortKey="Dardoufas, K" uniqKey="Dardoufas K">K Dardoufas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winczura, P" uniqKey="Winczura P">P Winczura</name></author><author><name sortKey="Jassem, J" uniqKey="Jassem J">J Jassem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trotti, A" uniqKey="Trotti A">A Trotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hardy, Rg" uniqKey="Hardy R">RG Hardy</name></author><author><name sortKey="Brown, Rm" uniqKey="Brown R">RM Brown</name></author><author><name sortKey="Miller, Sj" uniqKey="Miller S">SJ Miller</name></author><author><name sortKey="Tselepis, C" uniqKey="Tselepis C">C Tselepis</name></author><author><name sortKey="Morton, Dg" uniqKey="Morton D">DG Morton</name></author><author><name sortKey="Jankowski, Ja" uniqKey="Jankowski J">JA Jankowski</name></author><author><name sortKey="Sanders, Ds" uniqKey="Sanders D">DS Sanders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kouvaris, J" uniqKey="Kouvaris J">J Kouvaris</name></author><author><name sortKey="Kouloulias, V" uniqKey="Kouloulias V">V Kouloulias</name></author><author><name sortKey="Malas, E" uniqKey="Malas E">E Malas</name></author><author><name sortKey="Antypas, C" uniqKey="Antypas C">C Antypas</name></author><author><name sortKey="Kokakis, J" uniqKey="Kokakis J">J Kokakis</name></author><author><name sortKey="Michopoulos, S" uniqKey="Michopoulos S">S Michopoulos</name></author><author><name sortKey="Matsopoulos, G" uniqKey="Matsopoulos G">G Matsopoulos</name></author><author><name sortKey="Vlahos, L" uniqKey="Vlahos L">L Vlahos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leupin, N" uniqKey="Leupin N">N Leupin</name></author><author><name sortKey="Curschmann, J" uniqKey="Curschmann J">J Curschmann</name></author><author><name sortKey="Kranzbuhler, H" uniqKey="Kranzbuhler H">H Kranzbühler</name></author><author><name sortKey="Maurer, Ca" uniqKey="Maurer C">CA Maurer</name></author><author><name sortKey="Laissue, Ja" uniqKey="Laissue J">JA Laissue</name></author><author><name sortKey="Mazzucchelli, L" uniqKey="Mazzucchelli L">L Mazzucchelli</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Grèce</li></country></list><tree><country name="Grèce"><noRegion><name sortKey="Katsanos, Konstantinos H" sort="Katsanos, Konstantinos H" uniqKey="Katsanos K" first="Konstantinos H" last="Katsanos">Konstantinos H. Katsanos</name></noRegion><name sortKey="Bai, Maria" sort="Bai, Maria" uniqKey="Bai M" first="Maria" last="Bai">Maria Bai</name><name sortKey="Batistatou, Anna" sort="Batistatou, Anna" uniqKey="Batistatou A" first="Anna" last="Batistatou">Anna Batistatou</name><name sortKey="Briasoulis, Evangelos" sort="Briasoulis, Evangelos" uniqKey="Briasoulis E" first="Evangelos" last="Briasoulis">Evangelos Briasoulis</name><name sortKey="Capizzello, Antonio" sort="Capizzello, Antonio" uniqKey="Capizzello A" first="Antonio" last="Capizzello">Antonio Capizzello</name><name sortKey="Christodoulou, Dimitrios" sort="Christodoulou, Dimitrios" uniqKey="Christodoulou D" first="Dimitrios" last="Christodoulou">Dimitrios Christodoulou</name><name sortKey="Karavasilis, Vasileios" sort="Karavasilis, Vasileios" uniqKey="Karavasilis V" first="Vasileios" last="Karavasilis">Vasileios Karavasilis</name><name sortKey="Panelos, Ioannis" sort="Panelos, Ioannis" uniqKey="Panelos I" first="Ioannis" last="Panelos">Ioannis Panelos</name><name sortKey="Tolis, Christos" sort="Tolis, Christos" uniqKey="Tolis C" first="Christos" last="Tolis">Christos Tolis</name><name sortKey="Tsekeris, Pericles" sort="Tsekeris, Pericles" uniqKey="Tsekeris P" first="Pericles" last="Tsekeris">Pericles Tsekeris</name><name sortKey="Tsianos, Epameinondas V" sort="Tsianos, Epameinondas V" uniqKey="Tsianos E" first="Epameinondas V" last="Tsianos">Epameinondas V. Tsianos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000565 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000565 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= CobaltMaghrebV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2903531
|texte= Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20537164" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CobaltMaghrebV1
| This area was generated with Dilib version V0.6.32. |  |